...
The strains that look poised to drive the latest comeback are all subvariants of Omicron, which swept the globe over the past year. Several derived from BA.2, a strain that succeeded the initial BA.1 strain of Omicron but then was itself outcompeted in most places by BA.5, which has dominated in recent months. One of these, BA.2.75.2, seems to be spreading quickly in India, Singapore, and parts of Europe. Other new immune-evading strains have evolved from BA.5, including BQ.1.1, which has been spotted in multiple countries around the globe.
Despite their different origins, several of the new strains have chanced upon a similar combination of mutations to help scale the wall of immunity—a striking example of convergent evolution. They all have changes at half a dozen key points in the viral genome that influence how well neutralizing antibodies from vaccination or previous infection bind to the virus, says evolutionary biologist Jesse Bloom of the Fred Hutchinson Cancer Center. ...
Comments
- [global-health][4 other groups] Experts say that new...
Given these continued shifts, does one think the mono-clonal antibody therapy being still relevant?
I have my doubts.
Be Mindful, Be Active and Be Well!
Ed
Edward D Shanshala II, MSHSA, MSEd
Chief Executive Officer
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Sent: Wednesday, September 28, 2022 12:23 PM
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Subject: [EXTERNAL] - [global-health][4 other groups] Experts say that new strains suggest that a Big COVID-19 waves may be coming
COVID-19 waves may be coming, new Omicron strains suggest
Emerging subvariants have hit on a combination of mutations that makes them more immune evasive than ever
newsfromscience
...
The strains that look poised to drive the latest comeback are all subvariants of Omicron, which swept the globe over the past year. Several derived from BA.2, a strain that succeeded the initial BA.1 strain of Omicron but then was itself outcompeted in most
places by BA.5, which has dominated in recent months. One of these, BA.2.75.2, seems to be spreading quickly in India, Singapore, and parts of Europe. Other new immune-evading strains have evolved from BA.5, including BQ.1.1, which has been spotted in multiple
countries around the globe.
Despite their different origins, several of the new strains have chanced upon a similar combination of mutations to help scale the wall of immunity—a striking example of convergent evolution. They all have changes at half a dozen key points in the viral
genome that influence how well neutralizing antibodies from vaccination or previous infection bind to the virus, says evolutionary biologist Jesse Bloom of the Fred Hutchinson Cancer Center. ...
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