British scientists on Monday launched a trial which will deliberately expose participants who have already had COVID-19 to the coronavirus again to examine immune responses and see if people get reinfected.
In February, Britain became the first country in the world to give the go-ahead for so-called "challenge trials" in humans, in which volunteers are deliberately exposed to COVID-19 to advance research into the disease caused by the coronavirus. read more
The study launched on Monday differs from the one announced in February as it seeks to reinfect people who have previously had COVID-19 in an effort to deepen understanding about immunity, rather than infecting people for the first time.
"The information from this work will allow us to design better vaccines and treatments, and also to understand if people are protected after having COVID, and for how long," said Helen McShane, a University of Oxford vaccinologist and chief investigator on the study.
The first stage of the trial will seek to establish the lowest dose of the coronavirus needed in order for it to start replicating in about 50% of participants, while producing few to no symptoms. A second phase, starting in the summer, will infect different volunteers with that standard dose. ...
